Construction of the Xuanfu Theory Model for Podocytopathy
- VernacularTitle:肾小球足细胞病的玄府理论模型构建
- Author:
Shisheng HAN
1
;
Tianwen YAO
1
;
Yi WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: The Xuanfu theory; Podocyte; Nephrotic syndrome
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(10):2941-2949
- CountryChina
- Language:Chinese
- Abstract: The Xuanfu theory of Qi and liquid is an important theory guiding clinical practice of traditional Chinese medicine(TCM).Xuanfu and glomerular podocytes are highly consistent in terms of physiological structure,pathological phenotype,clinical characteristics,and therapeutic principles.Clinical applications of Xuanfu-opening therapy were observed to effectively mitigate podocyte injury and alleviate nephrotic syndrome due to podocytopathies.This article,based on clinical implementations of Xuanfu-opening therapy for podocytopathy,integrated evidence from Chinese and Western medical evidence to systematically establish the correlations between renal Xuanfu mechanisms and podocyte pathophysiology.Through rigorous comparative analysis,we elucidated the dynamic pathological progression spanning Xuanfu phases,including opening,constriction,obstruction,and atrophy and delineated its mechanistic association with podocyte injury cascades involving foot process effacement and apoptotic pathways.Furthermore,we proposed a therapeutic framework utilizing pungent-flavored phytochemicals as the core intervention for Xuanfu-opening therapy in podocytopathies,while constructing a preliminary theoretical model for Xuanfu-podocyte interactions.These findings provided references for TCM-based management for glomerular podocyte disorders and significantly enriched the medical connotation of the Xuanfu theory.
