Analysis of serum uric acid level correlated to coronary heart disease in 46 civil pilots
10.3760/cma.j.issn.1007-6239.2011.02.007
- VernacularTitle:46例民航飞行员血清尿酸水平与冠心病的相关分析
- Author:
Hui-min ZHANG
1
;
Peng HUANG
;
Ai-ping LIU
;
Chun-xia PENG
;
Bing-huai LU
;
Ding-qiong PENG
Author Information
1. 民航总医院空勤干部科,北京,100123
- Publication Type:Journal Article
- Keywords:
Uric acid;
Coronary disease;
Risk factors
- From:
Chinese Journal of Aerospace Medicine
2011;22(2):111-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the serum uric acid (SUA) level and the coronary heart disease (CHD) events in Chinese civil pilots. Methods Fasting blood samples were collected from 46 civil pilots who were likely diagnosed as CHD, and coronary arteriongraphy was conducted for final diagnosis in these subjects. The SUA levels, fasting blood glucose and blood lipid profile were measured and the correlation between CHD events and the above-mentioned biochemical results, history and age were statistically analyzed. Results Eighteen patients (39.1%) were diagnosed as CHD, while 28(60.9%) had no or minor abnormalities determined by coronary arteriongraphy, so as to be classified into CHD or non-CHD group respectively. The differences on age and the association of hypertension, low high density lipoprotein concentrations and hyperuricemia were significant between two groups (P<0.05), but on the association of diabetes, smoking, high cholesterol, high triglyceride and high low density lipoprotein concentrations (P>0.05). The mean SUA level in CHD group was significantly higher than that in non-CHD group [(430.58±89.10) μmol/L vs (341.70±78.11) μmol/L] (t=3.565, P<0.01). Furthermore, the exact Logistic regression indicated that the SUA concentration was the independent risk factor against CHD incidence. Conclusion The elevation of SUA might be an independent risk factor that induced CHD in pilot.
