A longitudinal study on the relationship between pre-pregnancy urolithiasis and pre-eclampsia: the mediating effect of hyperuricemia in early pregnancy
10.3760/cma.j.cn112338-20240701-00389
- VernacularTitle:孕前尿石症与子痫前期的纵向研究：孕早期高尿酸血症的中介效应
- Author:
Ye CHEN
1
;
Mengting SUN
1
;
Ziye LI
1
;
Qi ZOU
1
;
Yuan PENG
1
;
Xiaorui RUAN
1
;
Manjun LUO
1
;
Tingting WANG
1
;
Jiabi QIN
1
Author Information
1. 中南大学湘雅公共卫生学院流行病与卫生统计学系，长沙 410013
- Publication Type:Journal Article
- Keywords:
Urolithiasis;
Pre-eclampsia;
Hyperuricemia;
Mediation analysis
- From:
Chinese Journal of Epidemiology
2025;46(1):140-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between pre-pregnancy urolithiasis and pre-eclampsia and to further explore the mediating effect of hyperuricemia in early pregnancy on the relationship between urolithiasis and pre-eclampsia.Methods:Pregnant women attending prenatal care in early pregnancy at 7 Maternal and Child Health Hospitals in Hunan Province from August 2014 to December 2019 were recruited to construct a cohort of early pregnancy. The paper questionnaire collected demographic data on pregnant women, pre-pregnancy disease history, and living habits, etc. Besides, the early pregnancy laboratory examination and pregnancy outcome for this pregnancy were derived from the hospital's electronic medical record system. Logistic regression models were used to analyze the association between pre-pregnancy urolithiasis and pre-eclampsia, and causal mediation analysis was used to investigate the mediating role and magnitude of hyperuricemia in early pregnancy in the association pathway between pre-pregnancy urolithiasis and pre-eclampsia. Results:A total of 33 579 naturally conceived singleton pregnant women were included in the analysis, of which 3 230 cases (9.6%) had hyperuricemia in early pregnancy, and 666 cases (2.0%) had pre-eclampsia. The multivariate logistic regression analysis indicated that pre-pregnancy urolithiasis increased the risk of pre-eclampsia ( OR=2.65, 95% CI: 1.56-4.51). Mediation analysis showed that after controlling for confounders, hyperuricemia in early pregnancy could mediate the association between pre-pregnancy urolithiasis and pre-eclampsia, with a mediation effect proportion of 46% ( P<0.05). Conclusions:Pre-pregnancy urolithiasis is an independent risk factor for pre-eclampsia, and early pregnancy hyperuricemia has a certain mediating effect between urolithiasis and pre-eclampsia.
