Clinical analysis of 3 cases of vertically transmitted eschar-free scrub typhus in neonates
10.3760/cma.j.cn101070-20241203-00801
- VernacularTitle:垂直传播的新生儿无焦痂型恙虫病3例临床分析
- Author:
Mingliang ZHONG
1
;
Zengling SU
;
Yongjia CAI
;
Sitao LI
Author Information
1. 中山大学附属第六医院粤西医院/信宜市人民医院新生儿科，信宜 525300
- Publication Type:Journal Article
- Keywords:
Infant, newborn;
Scrub typhus;
Sepsis;
Metagenomic sequencing
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(10):780-782
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical manifestations and diagnosis, treatment experience of vertically transmitted eschar-free scrub typhus in newborns.Methods:A case summary was made.The clinical data of 3 newborns clinically diagnosed as vertically transmitted eschar-free scrub typhus and treated at the Department of Neonatology, the Sixth Affiliated Hospital, Sun Yat-sen University Yuexi Hospital/Xinyi People′s Hospital from August 2022 to July 2024 were retrospectively analyzed.Results:The age of onset of scrub typhus in the 3 newborns was within 24 h after birth.The children presented a fever, the clinical manifestations of early onset sepsis, and also multiple organ damage.Laboratory examination showed that all the 3 children have an abnormal elevation in C-reactive protein, a decrease of blood platelet (PLT) and an increase in D-dimer within 24 h after birth.The diagnosis was confirmed in all the patients via the metagenomic sequencing technology of pathogenic microorganism of blood samples.Two of the 3 children presented hepatomegaly and were treated with Azithromycin.All the children were clinically cured finally.Conclusions:The early clinical manifestation of vertically transmitted eschar-free scrub typhus in newborns is early onset sepsis and easily combined with multi-organ dysfunction, PLT reduction, and D-dimer elevation.Pathogenic microorganism metagenomic sequencing technology is conductive to the diagnosis of the disease, and Azithromycin is effective.
