Research Progress on the Pathogenesis of Non-Alcoholic Fatty Liver Disease and the Multi-Target Intervention Mechanism of Traditional Chinese Medicine
10.11842/wst.20250324005
- VernacularTitle:非酒精性脂肪性肝病的发病机制与中药多靶点干预机制的研究进展
- Author:
Chenlei GENG
1
;
Jinxia WEI
;
Xia LI
;
Yu YUAN
;
Lulu YU
;
Sijia LIU
;
Xingxu YAN
;
Jia SHAO
;
Meiling CHEN
Author Information
1. 天津中医药大学中药学院 天津 301617
- Publication Type:Journal Article
- Keywords:
Nonalcoholic fatty liver disease;
Traditional Chinese medicine;
Etiology and pathogenesis;
Mechanism of action research progress
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(10):2920-2927
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease caused by excessive lipid accumulation in the liver.Its incidence rate is increasing year by year and has become an increasingly serious public healthy problem.The pathogenesis of NAFLD is complex and has not been fully clarified at present.It is mainly related to multiple factors such as genetics,metabolism,intestinal flora and immune response.In order to explore the medication rules and mechanism of action of traditional Chinese medicine(TCM)in the treatment of NAFLD,and to provide references for the treatment of NAFLD with TCM and the research and development of new drugs,this article summarizes the TCM pathogenesis of NAFLD(such as"phlegm and blood stasis interlacing","liver depression and spleen deficiency",etc.)and modern etiology and pathogenesis(such as insulin resistance,lipid disorder,mitochondrial dysfunction,oxidative stress,etc.).The clinical research and experimental data at home and abroad in recent years were integrated to analyze the pathological process of NAFLD intervention by TCM through multiple targets,including improving insulin resistance and lipid metabolism disorders,inhibiting oxidative stress and mitochondrial dysfunction,etc.TCM has shown unique advantages in the prevention and treatment of NAFLD.However,the depth of its mechanism analysis and the level of clinical research still need to be improved.In the future,it is necessary to deepen the mechanism research by combining multi-omics technology to accelerate the modernization development of TCM.
