Research progress on metabolic reprogramming in aortic dissection
10.20039/j.cnki.1007-3949.2025.07.001
- VernacularTitle:代谢重编程在主动脉夹层中的研究进展
- Author:
Yangkai FAN
1
;
Kaixuan ZHANG
1
;
Yuan WANG
1
Author Information
1. 首都医科大学附属北京安贞医院心血管基础与转化医学研究中心 心血管重塑相关疾病教育部重点实验室心血管重大疾病防治协同创新中心;北京心肺血管疾病研究所,北京市 100029
- Publication Type:Journal Article
- Keywords:
aortic dissection;
metabolic reprogramming;
metabolic molecule;
biomarker
- From:
Chinese Journal of Arteriosclerosis
2025;33(7):553-562
- CountryChina
- Language:Chinese
-
Abstract:
Aortic dissection(AD)is a life-threatening acute vascular disease with a complex and not yet fully un-derstood pathogenesis.In recent years,metabolic reprogramming has gradually emerged as a significant factor in the oc-currence and development of AD.This review summarizes the abnormal alterations in major metabolic pathways,including amino acid metabolism,glucose metabolism,and lipid metabolism,and their impact on vascular cell functions in AD.Metabolic reprogramming contributes to the progression of AD by regulating the functions of endothelial cells(EC)and vascular smooth muscle cells(VSMC),thereby promoting the destruction of the vascular wall structure and exacerba-ting inflammatory responses.Additionally,this paper summarizes the potential applications of metabolism-related mole-cules in the early diagnosis and treatment of AD,emphasizing the importance of metabolic regulation as a novel strategy for AD prevention and management.Finally,future research directions in the study of metabolic reprogramming in AD are proposed,including in-depth mechanistic studies,the development of novel biomarkers,and the optimization of clinical in-tervention strategies,aiming to provide new insights and methods for the prevention and treatment of AD.
