Research status of salivary pepsin in laryngopharyngeal reflux disease
10.3760/cma.j.cn101070-20240829-00547
- VernacularTitle:唾液胃蛋白酶在咽喉反流性疾病中的研究现状
- Author:
Xiaohui MA
1
;
Chunhong JIANG
1
;
Jinzhun WU
1
Author Information
1. 厦门大学附属妇女儿童医院，厦门市妇幼保健院儿内科，厦门 361000
- Publication Type:Journal Article
- Keywords:
Laryngopharyngeal reflux disease;
Salivary pepsin;
Saliva detection;
Clinical significance
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(9):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Laryngopharyngeal reflux disease (LPRD) refers to a constellation of symptoms and signs resulting from the reflux of gastroduodenal contents above the upper esophageal sphincter.Current diagnostic challenges include non-specific clinical manifestations and the absence of standardized criteria or gold-standard detection methods.In recent years, salivary pepsin detection has gained significant clinical attention as a non-invasive, cost-effective tool for diagnosing LPRD and monitoring therapeutic efficacy.This review critically evaluates the diagnostic validity, clinical relevance, and limitations of salivary pepsin testing in LPRD management.
