Association between remnant cholesterol and the risk of atherosclerotic cardiovascular disease in a community population in Shanghai
10.3760/cma.j.cn112338-20241018-00641
- VernacularTitle:上海市社区人群残余胆固醇与动脉硬化性心血管疾病发生风险的关联研究
- Author:
Yingqi DENG
1
;
Minhua TANG
;
Kexin ZHANG
;
Xiaohua LIU
;
Yanan WU
;
Qian PENG
;
Liping YI
;
Jianhua SHI
;
Yingfeng LU
;
Yonggen JIANG
;
Genming ZHAO
Author Information
1. 复旦大学公共卫生学院，上海 200032
- Publication Type:Journal Article
- Keywords:
Remnant cholesterol;
Atherosclerotic cardiovascular disease;
Cohort studies
- From:
Chinese Journal of Epidemiology
2025;46(6):935-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between remnant cholesterol (RC) and the risk of atherosclerotic cardiovascular disease (ASCVD) in community population in Shanghai.Methods:Using baseline and follow-up data from the Shanghai Suburban Adult Cohort and Biobank, individuals with ASCVD (including coronary heart disease, stroke, myocardial infarction, and peripheral artery disease) at baseline were excluded. A Cox proportional hazards regression model was employed to analyze the relationship between RC and ASCVD risk and the association under different LDL-C levels.Results:A total of 57 281 participants were included, with a median follow-up of 5.61 person-years. During the follow-up, 1 436 ASCVD events (2.51%) were recorded. After adjusting for potential confounders, individuals with moderate ( HR=1.18, 95% CI: 1.03-1.36) or high RC levels ( HR=1.32, 95% CI: 1.15-1.51) had an increased risk of ASCVD. The association was stronger in participants younger than 60 years-old (interaction P=0.048). Participants with RC ≥0.97 mmol/L and LDL-C <3.40 mmol/L demonstrated a 19% ( HR=1.19, 95% CI: 1.06-1.35) increased risk of ASCVD. When RC ≥0.97 mmol/L and LDL-C ≥3.40 mmol/L, ASCVD risk increased by 42% ( HR=1.42, 95% CI: 1.21-1.67). Conclusions:Elevated RC increases ASCVD risk, regardless of LDL-C levels. RC can serve as a valuable predictor and intervention target for ASCVD.
