Progress on haploidentical hematopoietic stem cell transplantation for the treatment of acquired severe aplastic anemia in children
10.3760/cma.j.cn101070-20240919-00605
- VernacularTitle:单倍体造血干细胞移植治疗儿童获得性重型再生障碍性贫血的研究进展
- Author:
Danqi LUO
1
;
Yuhua QU
1
;
Haiyan LIU
1
;
Hua JIANG
1
Author Information
1. 广州医科大学附属妇女儿童医疗中心血液肿瘤科，广州 510623
- Publication Type:Journal Article
- Keywords:
Child;
Aplastic anemia;
Haploidentical hematopoietic stem cell transplantation
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(9):713-717
- CountryChina
- Language:Chinese
-
Abstract:
Acquired severe aplastic anemia (SAA) in children is a bone marrow failure disease characterized by reduced proliferation of marrow nucleated cells and decreased peripheral blood levels of two or three blood cell lines.Treatment options mainly include immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation.The primary advantage of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is the availability of a donor for nearly everyone.With ongoing improvements in conditioning regimens, haploidentical hematopoietic stem cell transplantation has made significant progress.This paper aims to review the research progress on haplo-HSCT for treating acquired SAA in children, providing reference for clinical practice.
