Research progress of histamine in neuroinflammatory mechanism of tic disorder
10.3760/cma.j.cn101070-20240913-00592
- VernacularTitle:组胺在抽动障碍神经炎症机制中的研究进展
- Author:
Qianying LIU
1
;
Guizhi XIA
;
Shuyao CHEN
Author Information
1. 福建医科大学福总临床医学院儿科，福州 350001
- Publication Type:Journal Article
- Keywords:
Tic disorder;
Histamine;
Neuroinflammation
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(9):709-712
- CountryChina
- Language:Chinese
-
Abstract:
Tic disorder is a common neurodevelopmental disorder characterized by motor or vocal tics.The etiology and pathogenesis have not been fully elucidated.Increasingly, studies have shown that immune-mediated chronic inflammation of the nervous system plays an important role in the onset and progression of tic disorder.Histamine is an endogenous biogenic amine with peripheral and central immunomodulatory functions, which plays a crucial role in regulating the cortex-striatum-thalamus-cortex circuit, and exerts dual effects in the process of neuroinflammation.This review aims to investigate the pathological mechanism of histamine in the neuroinflammation of tic disorder.
