Effects of psychological stress combined with sleep deprivation on learning memory ability and certain nutrients in rats
10.3760/cma.j.issn.1009-6906.2010.03.004
- VernacularTitle:心理应激复合睡眠剥夺对大鼠学习记忆能力和部分营养素的影响
- Author:
Jia-qing HU
1
;
Ling-huo XU
;
Xiao-hua WANG
;
Yi-yi OU
;
Hong-yuan ZHOU
;
Jian-cheng ZHANG
;
Ming YIN
Author Information
1. 海军医学研究所,上海,200433
- Publication Type:Journal Article
- Keywords:
Psychological stress;
Sleep deprivation;
Learning memory ability;
Nutrient
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2010;17(3):140-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of successive 14 d psychological stress combined with 48 h sleep deprivation on learning memory and certain nutrients in rats.Methods Forty-five male SD rats were randomly divided into 3 groups,each consisting of 15 animals;the blank control group,the multi-factor group and the multi-factor negative control group.The psychological stress coupled with sleep deprivation model was developed with the Communication Box and a small modified platform.Learning memory of rats was measured by the Morris water maze.Serum samples were taken from the rats to measure levels of Vc、Ve、Fe and CK activity.Results Following multi-factor intervention,escape latency of rats for total-quadrant,the first and the second quadrant were significantly longer than those of the control group,and Fe concentration decreased obviously.Conclusions Fourteen-day psychological stress coupled with 48-hour sleep deprivation could impair learning memory of rats,and induced deficiency of certain nutrients in rats.
