Effects of HIF-1α on cell function through regulating TRPV channel

VernacularTitle:HIF-1α通过调控TRPV通道对细胞功能的影响
Author: Mei SHI ¹ ; Yunping TANG ¹ ; Jiangwei LIU ¹ ; Xianzhong WANG ¹ ; Jiaojiao ZHANG ¹
Author Information

1. 西南大学动物医学院,重庆 400715
Publication Type:Journal Article
Keywords: HIF-1α; TRPV; low temperature plasma
From: Chinese Journal of Veterinary Science 2025;45(8):1784-1791,1800
CountryChina
Language:Chinese
Abstract: Cell is the most basic unit of life,and normal metabolism is the key to cell growth and development.Reactive oxygen species(ROS)are important regulators of cell function,and hypoxi-a-inducible factor-1 alpha(HIF-1α)is a ROS receptor,which can activate transient receptor poten-tial vanilloid(TRPV)channel.TRPV is a sensor for temperature,pain,and osmotic pressure.Changes in the environment can induce changes in the activity of TRPV channel,which regulates various physiological and pathological processes of cells through its downstream signaling path-ways.Low temperature plasma can regulate cellular TRPV channel activity through HIF-1α.This article mainly reviews the effect of HIF-1α on cell function through TRPV channel,which has ref-erence significance for future research on various diseases related to TRPV channel and their pre-vention and treatment,as well as provides a new idea for using low temperature plasma technology to treat diseases through regulating TRPV channel.