Clinicopathological features and molecular genetic advances in gastric adenocarci-noma of fundic gland type
10.13315/j.cnki.cjcep.2025.07.013
- VernacularTitle:胃底腺型腺癌的临床病理学特征及分子遗传学进展
- Author:
Xiafei GU
1
;
Jianping LIU
1
Author Information
1. 四川大学华西医院病理科,成都 610000
- Publication Type:Journal Article
- Keywords:
gastric adenocarcinoma of fundic gland type;
chief cell;
parietal cell;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(7):924-928,934
- CountryChina
- Language:Chinese
-
Abstract:
Gastric adenocarcinoma of fundic gland type(GA-FG)is a newly reported gastric tumor,which is a highly differentiated adenocarcinoma with a better prognosis.It has been included in the 2019 WHO Classification of Digestive Tumors.However,further knowledge is still needed for GA-FG clinically and pathologically.GA-FG is divid-ed into 3 types,including chief cell-predominant,parietal cell-predominant,and mixed cell-predominant.Diagnosis and differential diagnosis mainly rely on pathohistological morphology and immunohistochemistry.This article reviews the clinical features,endoscopy,electron microscopy,histologic morphology,immunohistochemistry,possible molecu-lar mechanisms and prognosis of GA-FG.The aim is to enable clinicians and pathologists to keep abreast of new ad-vances in the disease and to improve diagnosis and treatment.
