Improving the application of metagenomic next-generation sequencing for pathogen diagnosis in infections related to hematological diseases
10.3760/cma.j.cn121090-20241029-00423
- VernacularTitle:正确认识病原微生物宏基因组二代测序技术在血液病感染病原诊断中的价值
- Author:
Sizhou FENG
1
;
Chunhui XU
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津 300020
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2024;45(11):982-985
- CountryChina
- Language:Chinese
-
Abstract:
Patients with hematologic diseases are prone to infections, and infection-related mortality is high in this population. Accurate diagnosis of infectious pathogens is crucial; however, conventional microbiological testing often fails to meet clinical needs, presenting a significant challenge in clinical practice. Metagenomic next-generation sequencing (mNGS), with its high sensitivity, broad coverage, and short turnaround time, has been widely adopted in diagnosing infectious diseases. This article focuses on the application of mNGS technology in diagnosing infectious pathogens in patients with hematologic diseases. It analyzes the challenges encountered in clinical practice and explores future trends in the field. This work aims to provide clinicians with an in-depth understanding of the value and limitations of mNGS in diagnosing infections in hematologic patients, and to promote its rational application.
