Mechanism and treatment progress of Desmopressin-resistant monosymptomatic nocturnal enuresis with nocturnal polyuria in children
10.3760/cma.j.cn101070-20241106-00721
- VernacularTitle:儿童去氨加压素抵抗性夜间多尿型单症状遗尿症的机制及治疗进展
- Author:
Yusen ZHU
1
;
Peipei SHI
1
;
Jianjiang ZHANG
1
Author Information
1. 郑州大学第一附属医院儿科，河南省儿童肾脏病临床诊疗中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Nocturnal enuresis;
Nocturnal polyuria;
Child;
Desmopressin-resistant;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(11):877-880
- CountryChina
- Language:Chinese
-
Abstract:
Nocturnal enuresis (NE) is a common pediatric disease with unclear pathogenesis.The prevailing hypothesis is that NE is caused by a discrepancy between nocturnal urine output and bladder capacity and sleep-wake disturbances.Monosymptomatic nocturnal enuresis (MNE) with nocturnal polyuria is a common subtype of NE, which can be effectively treated by Desmopressin.However, it is possible that some children may demonstrate an inability to respond favorably to this form of therapy and become resistant to it, which significantly impacts their physical and mental health and overall quality of life.In this article, recent advances in the pathogenesis and treatment of Desmopressin-resistant MNE with nocturnal polyuria in children were reviewed to provide a reference for its treatment.
