Clinicopathological analysis of 10 cases of diffuse pulmonary meningotheliomatosis
10.13315/j.cnki.cjcep.2025.09.012
- VernacularTitle:弥漫性肺脑膜上皮瘤病10例临床病理分析
- Author:
Shicui QUAN
1
;
Nian WANG
;
Zhiling XIE
;
Qin LIU
;
Qiong WANG
;
Weifeng WEI
;
Naijian LI
;
Ping HE
;
Jin-lin WANG
Author Information
1. 广州医科大学附属第一医院病理科,广州 510120
- Publication Type:Journal Article
- Keywords:
diffuse pulmonary meningotheliomatosis;
clinicopathological characteristics;
pulmonary nodules;
immuno-histochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(9):1194-1199
- CountryChina
- Language:Chinese
-
Abstract:
Purpose This study aims to investigate the clinicopathological features of diffuse pulmonary menin-gotheliomatosis(DPM).Methods The clinical data of 10 patients with DPM undergoing video-assisted thoracic sur-gery(VATS)were collected,and their clinical and pathological characteristics were analyzed using immunohistochem-istry.Results The detection rate of DPM was 1.19‰,with 90％of the patients being female.DPM predominantly occurred in the age range of 40-60 years,with an average age at diagnosis of 50.7 years.Most patients had no smok-ing history.Pathological diagnosis combined with imaging findings was the main method for diagnosing DPM.80％of the patients were prone to concurrent early-stage invasive pulmonary adenocarcinoma.Laboratory indicators,including pulmonary function,were generally normal.Chest CT showed diffuse multiple ground-glass opacity or cystic nodules in both lungs,with the number of nodules in both lungs ranging from dozens to hundreds,and the maximum diameter of the nodules was 2-6 mm.The median volume and CT value of the pulmonary nodules were 35.32 mm3 and-566 HU,respectively.Pathological features mainly included multiple meningothelial-like nodules observed under the micro-scope.Immunophenotypically,CD56,EMA,PR,and vimentin were often positive.Conclusion DPM is a rare lung disease with no obvious clinical symptoms,and is more common in middle-aged and elderly women.Diffuse multiple nodules in both lungs are its main imaging features.Most DPM patients are complicated with lung adenocarcinoma,and regular follow-up is recommended.
