Mechanisms of laryngopharyngeal reflux in children
10.3760/cma.j.cn101070-20250501-00321
- VernacularTitle:儿童咽喉反流发生机制
- Author:
Xiaoyin TIAN
1
;
Zhengxiu LUO
1
Author Information
1. 重庆医科大学附属儿童医院呼吸科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童重要器官发育与疾病重庆市卫健委重点实验室，重庆 401122
- Publication Type:Journal Article
- Keywords:
Child;
Laryngopharyngeal reflux;
Mechanism
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(11):823-827
- CountryChina
- Language:Chinese
-
Abstract:
Laryngopharyngeal reflux (LPR) refers to the reflux of gastroduodenal contents into the upper aerodigestive tract above the upper esophageal sphincter, including the nasopharynx, oropharynx, hypopharynx, and larynx, etc.It can lead to morphological changes in the upper aerodigestive tract as well as a series of symptoms and signs.The mechanism of LPR in children remains incompletely understood.Anatomical and physiological factors provide predisposing conditions for LPR in children, making them more vulnerable to refluxate injury.The direct damage to the laryngopharyngeal mucosa by the refluxate, inflammatory responses, and indirect injury triggered by neuroreflex mechanisms collectively contribute to the onset and progression of LPR.In this article, recent advances in research on the mechanism underlying pediatric LPR are reviewed, aiming to provide a theoretical basis for clinical practice.
