Impacts of preoperative regional arterial infusion chemotherapy com-bined with laparoscopic surgery on patients with colorectal cancer
10.3969/j.issn.1009-9905.2025.07.003
- VernacularTitle:术前区域动脉灌注化疗联合腹腔镜手术对结直肠癌患者的影响
- Author:
Jin-feng WANG
1
;
Lei PENG
;
Bao FU
;
Xiao-he CHEN
Author Information
1. 石家庄市中医院 外科(河北 石家庄 052360)
- Publication Type:Journal Article
- Keywords:
Preoperative regional arterial infusion chemotherapy;
Laparoscopic surgery;
Colorectal cancer;
Clinical efficacy;
Immune function
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(7):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impacts of preoperative regional arterial infusion chemotherapy(PRAC)combined with laparoscopic surgery on the efficacy,safety,immune function,and serum levels of matrix metallopro-teinase-7(MMP-7)and human cartilage glycoprotein(YKL-40)in patients with colorectal cancer.Methods:This study retrospectively selected 164 patients with colorectal cancer(January 2014 to December 2016)as the research subjects.Patients who underwent conventional treatment and laparoscopic surgery were included into control group(81 cases);patients undergoing PRAC+laparoscopic surgery were included into observation group(83 cases).The clinical efficacy,stress response indicators,immune function related indicators,changes in serum MMP-7 and YKL-40 levels,and occurrence of adverse reactions in two groups were observed before treatment(T0)and after 4 cycles of chemotherapy(T1).Results:At T1,the total effective rate of observation group(85.54%)was greatly higher than that of control group(67.90%)(P<0.05).The levels of cortisol(Cor),neutrophile granulocyte(NE),white blood cell count(WBC),and interleukin(IL)-6 were prominently increased in both groups(P<0.05),but the levels of these indicators in observation group were greatly lower than those in control group(P<0.05).The levels of IgM and IgA in both groups were greatly reduced(P<0.05),but the levels of IgM and IgA in observation group were prominently higher than those in control group(P<0.05).The levels of MMP-7 and YKL-40 decreased in both groups(P<0.05),and the level in observation group was prominently lower than that in control group(P<0.05).There was no significant difference in the overall incidence of adverse reactions and 5-year survival rate between control group and observation group(P>0.05).Conclusion:The combination of PRAC and laparoscopic surgery has prominent healing effects and certain safety in patients with colorectal cancer.It can effectively improve immune function,reduce serum MMP-7 and YKL-40 levels.
