Windy Flaming Wheels Running in Reverse
10.13865/j.cnki.cjbmb.2024.03.1371
- VernacularTitle:倒转的风火轮——还原型三羧酸循环微课设计
- Author:
Zhi DING
1
;
Yang SUN
;
Feng ZHANG
Author Information
1. 南京大学生命科学学院生物化学系,南京 210023
- Publication Type:Journal Article
- Keywords:
reductive tricarboxylic acid cycle(RTAC);
micro-lecture design;
anabolic metabolism;
carbon fixation
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):1068-1075
- CountryChina
- Language:Chinese
-
Abstract:
Adhering to the educational tenet of"student-centered",we have integrated a micro-lecture on Reductive Tricarboxylic Acid Cycle into biochemistry to foster scientific research engagement and critical thinking skills of students-particularly those enrolled in the Outstanding and Foundation Strengthening programs.It supplements and deepens the content of the chapter Tricarboxylic Acid Cycle.In the micro-lecture we first summarize the characteristics of the oxidative tricarboxylic acid cycle,which releases wind(carbon dioxide)and fire(energy).The cycle is therefore considered as a windy and flaming wheel,a powerful Nimbus-like vehicle from a famous Chinese legendary.Students are then guided through a step-by-step analysis of the molecular basis of the reduced tricarboxylic acid cycle,which reverses the wheel to absorb wind and fire and complete carbon fixation,following the First Law of thermodynamics.Finally,the discovery of this cycle is traced and the scientific and social significance of this discovery is highlight-ed.This course has achieved good results in practical teaching applications.Therefore,we present the design ideas,innovative features,highlights,and implementation outcomes of this micro-lecture,inviting peer review and constructive feedback to facilitate collaborative refinement.
