Metastatic mechanisms of cutaneous squamous cell carcinoma
- VernacularTitle:皮肤鳞状细胞癌转移机制的研究进展
- Author:
Ping ZHU
1
;
Daguang WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Neoplasms, squamous cell; Neoplasm Metastasis; Immunosuppression; Risk factor; Signal transduction; Molecular pathways
- From: Chinese Journal of Dermatology 2025;58(2):186-189
- CountryChina
- Language:Chinese
- Abstract: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor, and metastatic cSCC usually has a poor prognosis. Many factors influence the metastasis of cSCC, including primary lesion diameter, anatomical location, immunosuppression, clinical types, depth of tumor invasion, degree of differentiation, and vascular, perineural, and lymphatic invasion. Multiple intracellular signaling pathways drive tumor metastasis, such as Wnt/β-catenin, transforming growth factor β, and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway. This review discusses the factors influencing cSCC metastasis and the role of the above signaling pathways in the metastatic mechanisms of cSCC, providing new insights for the treatment of metastatic cSCC.
