Molecular mechanisms of high-risk neuroblastoma occurrence and development
10.3760/cma.j.cn101070-20240728-00479
- VernacularTitle:高危神经母细胞瘤发生发展的分子机制
- Author:
Hongjun FAN
1
;
Yan SU
1
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院儿童肿瘤中心肿瘤内科，儿童肿瘤国家临床重点专科，首都医科大学基础－临床联合实验室（儿童肿瘤发病机制与创新药物研究实验室），儿科重大疾病研究教育部重点实验室，北京 100045
- Publication Type:Journal Article
- Keywords:
Neuroblastoma;
High-risk;
Evolution;
Etiology
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(6):469-473
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma is a highly heterogeneous extracranial malignant solid tumor commonly detected in children.Over the past decade, with the application of second-generation sequencing technologies such as whole-exome sequencing and whole-genome sequencing, chromatin immunoprecipitation and other techniques, the mechanisms underlying the occurrence and development of high-risk neuroblastoma have gradually become clearer.In this article, recent key molecular events that have been elucidated in the occurrence and development of high-risk neuroblastoma are reviewed.
