Changing distribution and antimicrobial resistance profiles of clinical isolates in children:results from the CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015-2021年CHINET儿童患者临床分离菌的分布特征和耐药性变迁
- Author:
Qing MENG
1
;
Lintao ZHOU
;
Yunsheng CHEN
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Chuanqing WANG
;
Aimin WANG
;
Lei ZHU
;
Jinhua MENG
;
Hong ZHANG
;
Chun WANG
;
Fang DONG
;
Zhiyong LÜ
;
Shuping ZHOU
;
Yan ZHOU
;
Shifu WANG
;
Fangfang HU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Zhaoxia ZHANG
;
Ping JI
;
Wei JIA
;
Gang LI
;
Kaizhen WEN
;
Yirong ZHANG
;
Yan JIN
;
Chunhong SHAO
;
Yong ZHAO
;
Ping GONG
;
Chao ZHUO
;
Danhong SU
;
Bin SHAN
;
Yan DU
;
Sufang GUO
;
Jiao FENG
;
Ziyong SUN
;
Zhongju CHEN
;
Wen'en LIU
;
Yanming LI
;
Xiaobo MA
;
Yanping ZHENG
;
Dawen GUO
;
Jinying ZHAO
;
Ruizhong WANG
;
Hua FANG
;
Lixia ZHANG
;
Juan MA
;
Jihong LI
;
Zhidong HU
;
Jin LI
;
Yuxing NI
;
Jingyong SUN
;
Ruyi GUO
;
Yan ZHU
;
Yi XIE
;
Mei KANG
;
Yuanhong XU
;
Ying HUANG
;
Shanmei WANG
;
Yafei CHU
;
Hua YU
;
Xiangning HUANG
;
Lianhua WEI
;
Fengmei ZOU
;
Han SHEN
;
Wanqing ZHOU
;
Yunzhuo CHU
;
Sufei TIAN
;
Shunhong XUE
;
Hongqin GU
;
Xuesong XU
;
Chao YAN
;
Bixia YU
;
Jinju DUAN
;
Jianbang KANG
;
Jiangshan LIU
;
Xuefei HU
;
Yunsong YU
;
Jie LIN
;
Yunjian HU
;
Xiaoman AI
;
Chunlei YUE
;
Jinsong WU
;
Yuemei LU
Author Information
- Publication Type:Journal Article
- Keywords: bacterial resistance surveillance; antimicrobial susceptibility testing; methicillin-resistant Staphylococcus; carbapenem-resistant Enterobacterales
- From: Chinese Journal of Infection and Chemotherapy 2025;25(1):48-58
- CountryChina
- Language:Chinese
- Abstract: Objective To understand the changing composition and antibiotic resistance of bacterial species in the clinical isolates from outpatient and emergency department(hereinafter referred to as outpatients)and inpatient children over time in various hospitals,and to provide laboratory evidence for rational antibiotic use.Methods The data on clinically isolated pathogenic bacteria and antimicrobial susceptibility of isolates from outpatients and inpatient children in the CHINET program from 2015 to 2021 were collected and analyzed.Results A total of 278 471 isolates were isolated from pediatric patients in the CHINET program from 2015 to 2021.About 17.1％of the strains were isolated from outpatients,primarily group A β-hemolytic Streptococcus,Escherichia coli,and Staphylococcus aureus.Most of the strains(82.9％)were isolated from inpatients,mainly SS.aureus,E.coli,and H.influenzae.The prevalence of methicillin-resistant S.aureus(MRSA)in outpatients(24.5％)was lower than that in inpatient children(31.5％).The MRSA isolates from outpatients showed lower resistance rates to the antibiotics tested than the strains isolated from inpatient children.The prevalence of vancomycin-resistant Enterococcus faecalis or E.faecium and penicillin-resistant S.pneumoniae was low in either outpatients or inpatient children.S.pneumoniae,β-hemolytic Streptococcus and S.viridans showed high resistance rates to erythromycin.The prevalence of erythromycin-resistant group A β-hemolytic Streptococcus was higher in outpatients than that in inpatient children.The prevalence of β-lactamase-producing H.influenzae showed an overall upward trend in children,but lower in outpatients(45.1％)than in inpatient children(59.4％).The prevalence of carbapenem-resistant Klebsiella pneumoniae(CRKpn),carbapenem-resistant Pseudomonas aeruginosa(CRPae)and carbapenem-resistant Acinetobacter baumannii(CRAba)was 14％,11.7％,47.8％in outpatients,but 24.2％,20.6％,and 52.8％in inpatient children,respectively.The prevalence of multidrug-resistant E.coli,K.pneumoniae,Proteus mirabilis,P.aeruginosa and A.baumannii strains was lower in outpatients than in inpatient children.The prevalence of fluoroquinolone-resistant E.coli,ESBLs-producing K.pneumoniae,ESBLs-producing P.mirabilis,carbapenem-resistant E.coli(CREco),CRKpn,and CRPae was lower in children in outpatients than in inpatient children,but the prevalence of CRAba in 2021 was higher than in inpatient children.Conclusions The distribution of clinical isolates from children is different between outpatients and inpatients.The prevalence of MRSA,ESBL,and CRO was higher in inpatient children than in outpatients.Antibiotics should be used rationally in clinical practice based on etiological diagnosis and antimicrobial susceptibility test results.Ongoing antimicrobial resistance surveillance and prevention and control of hospital infections are crucial to curbing bacterial resistance.
