Application of single-cell sequencing in the hair research
- VernacularTitle:单细胞测序在毛发相关研究中的应用
- Author:
Jie YANG
1
;
Liping LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Hair; Hair follicle; Sequence analysis, DNA; Single-cell sequencing; Alopecia; Hair graying
- From: Chinese Journal of Dermatology 2025;58(7):690-694
- CountryChina
- Language:Chinese
- Abstract: Hair follicles are complex organs consisting of multiple cell types. Single-cell sequencing technology can identify the transcriptional characteristics of various cell types and subsets in tissues at the single-cell level, comprehensively revealing the heterogeneity among cell populations. This review focuses on the latest advances in the application of single-cell sequencing to the study on molecular characteristics of mouse and human hair follicle cells and cell fate regulation, as well as aging, microbial symbiosis, and the pathogenesis of hair loss and hair graying. Single-cell sequencing can serve as a novel tool for studying the morphogenesis, cell types, physiological and pathological states of hair follicles, and has revealed important information that had not been found in traditional research, which is meaningful for hair-related studies.
