Correlation between plasma soluble triggering receptor expressed on myeloid cell-1 and steroids and disease severity in patients with pulmonary tuberculosis
10.16718/j.1009-7708.2025.01.001
- VernacularTitle:血浆可溶性髓样细胞触发受体-1、类固醇激素与肺结核患者疾病严重程度的相关性
- Author:
Yingqiao YANG
1
;
Yan LI
;
Xuyan XU
Author Information
1. 湖北科技学院临床医学院内科,湖北咸宁 437000;湖北科技学院附属第一医院(咸宁市中心医院)呼吸与危重症医学科
- Publication Type:Journal Article
- Keywords:
soluble triggering receptor expressed on myeloid cell-1;
pulmonary tuberculosis;
severe pulmonary tuberculosis;
immunoendocrine marker
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between baseline plasma soluble triggering receptor expressed on myeloid cell-1(sTREM-1),steroid hormone cortisol and dehydroepiandrosterone(DHEA),immunoendocrine markers,and disease severity in patients with pulmonary tuberculosis(PTB).Methods From March 2020 to May 2022,76 PTB patients and 78 healthy controls were recruited.The plasma sTREM-1 levels were compared between controls and PTB patients.Plasma sTREM-1 and C-reactive protein(CRP),interleukin(IL)-6 and interferon(IFN)-y,erythrocyte sedimentation rate(ESR),steroid hormone cortisol and dehydroepiandrosterone(DHEA)were analyzed to correlate with inflammatory transcripts(IL-6,IFN-γ)in peripheral blood mononuclear cells.Results The sTREM,CRP,ESR,IL-6,IFN-γ,cortisol and cortisol/DHEA were significantly increased(P＜0.05)while DHEA was significantly decreased(P＜0.05)in PTB patients compared with the control group.Futhermore,severe PTB patients had higher sTREM-1 and ESR levels than mild and moderate PTB patients.Spearman correlation analysis showed that sTREM-1 was significantly positively correlated with CRP in all patients(P＜0.05).Only in patients with severe PTB,sTREM-1 was significantly positively correlated with cortisol/DHEA(P＜0.05),and significantly negatively correlated with DHEA(P＜0.05).Conclusions High plasma sTREM-1 levels may be an important factor contributing to the persistence of immunoendocrine imbalance specific to advanced disease in patients with PTB.
