Brain structure and morphology changes in patients with chronic knee osteoarthritis
10.3969/j.issn.1001-1242.2025.03.008
- VernacularTitle:慢性膝骨关节炎患者大脑结构形态的改变
- Author:
Jin YE
1
;
Yiyu WU
;
Chi ZHANG
Author Information
1. 福建中医药大学附属康复医院,福建省 福州市,350003;福建省康复技术重点实验室;福建中医药大学康复医学院
- Publication Type:Journal Article
- Keywords:
knee osteoarthritis;
magnetic resonance imaging;
gray matter volume;
sulcus depth;
structural co-variance networks
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(3):369-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of brain structure and morphology changes in patients with chronic knee osteoarthritis(OA).Method:Voxel-based morphometry(VBM)analysis,surface-based morphometry(SBM)analysis and structural covariance networks(SCN)based on gray matter volume were used to exam the differences in brain structure and morphology between patients with chronic knee osteoarthritis(KO A)and healthy control(HC).Result:①VBM analysis:Compared with HC subjects,chronic KOA patients showed a significant reduction in gray matter volume of the left temporal pole as the central region(voxels level,P＜0.001;cluster level,P=0.049,FWE correction,voxels size=833).②SBM analysis:Compared with HC subjects,the sulcus depth in the pars opercularis of the left inferior frontal gyrus decreased significantly in patients with chronic KOA(voxels level,P＜0.001;cluster level,P=0.003,FWE correction,voxels size=293).③SCN analysis:Compared with HC subjects,the SCN constructed based on local gray matter volume in patients with chronic KOA was more robust than that in healthy controls(P=0.032).Conclusion:Chronic KOA patients have structural abnormalities in the brain,providing a new insights into the potential impact of chronic KOA on the central nervous system.
