Research progress in animal models of pulpitis
10.3760/cma.j.cn112144-20250714-00264
- VernacularTitle:牙髓炎动物模型的研究进展
- Author:
Kexin XU
1
;
Lijun HUO
1
;
Rui SHE
1
;
Xinye LI
1
;
Jinyan WU
1
Author Information
1. 昆明医科大学附属口腔医院牙体牙髓病科 云南省口腔医学重点实验室，昆明650000
- Publication Type:Journal Article
- Keywords:
Pulpitis;
Models, animal;
Experimental animals;
Modeling methods;
Evaluation indicators
- From:
Chinese Journal of Stomatology
2025;60(11):1292-1299
- CountryChina
- Language:Chinese
-
Abstract:
Pulpitis is a prevalent inflammatory disease in dentistry, and root canal therapy remains the primary clinical treatment for it. However, pulp removal leads to reduced tooth fracture resistance and complications such as secondary infection and tooth fracture. As a potential alternative, vital pulp therapy (VPT) relies on precise assessment of pulp status; yet current clinical diagnostic methods lack specificity. The establishment of appropriate animal models for pulpitis is crucial for investigating its pathogenesis, developing specific diagnostic biomarkers, and optimizing VPT strategies. This review systematically summarizes experimental animals selection based on anatomical compatibility and pathological similarity, as well as model construction methods and multimodal evaluation systems for pulpitis animal models, aiming to provide insights for related researches.
