Incidence of Major Adverse Cardiovascular and Cerebrovascular Events in Chinese Patients Undergoing Percutaneous Coronary Intervention with Iodixanol: An Observational Postauthorization Study
10.1097/CD9.0000000000000065
- VernacularTitle:Incidence of Major Adverse Cardiovascular and Cerebrovascular Events in Chinese Patients Undergoing Percutaneous Coronary Intervention with Iodixanol: An Observational Postauthorization Study
- Author:
Xiaozeng WANG
1
;
Dengfeng MA
;
Tianchang LI
;
Bao LI
;
Xi SU
;
Yanqing WU
;
Zhimin DU
;
Zheng JI
;
Ping YANG
;
Baisong YANG
;
Xuebin CAO
;
Junxia LI
;
Fengxia HOU
;
Ziping CHENG
;
Banglong XU
;
Yaling HAN
Author Information
1. General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, China
- Publication Type:Journal Article
- Keywords:
Percutaneous coronary intervention;
Contrast medium;
Adverse event;
Major adverse cardiovascular and cerebrovascular event;
Contrast-induced acute kidney
- From:
Cardiology Discovery
2023;03(2):95-101
- CountryChina
- Language:English
-
Abstract:
Objective::This study aimed to evaluate the major adverse cardiovascular and cerebrovascular events (MACCEs) and overall safety profile associated with iodixanol in Chinese patients undergoing percutaneous coronary intervention (PCI).Methods::Patients at 30 centers in China registered in the OpenClinic v3.6 database from October 30, 2013, to October 7, 2015, were included in the study. The primary endpoint was in-hospital MACCEs including target lesion revascularization (TLR), stroke, stent thrombosis, cardiac death, and PCI-related myocardial infarction (MI) within 72 h post-PCI. Secondary endpoints were MACCEs from 72 h to 30 d post-PCI and other safety events within 30 d post-PCI.Results::A total of 3,042 patients were enrolled. The incidence of MACCEs within 72 h post-PCI was 2.33% ( n = 71), including cardiac death (0.03%, n = 1) and PCI-related MI (2.30%, n = 70). The incidence of MACCEs from 72 h to 30 d post-PCI was 0.16% ( n = 5), including cardiac death (0.10%, n = 3), PCI-related MI (0.03%, n = 1), and TLR for stent thrombosis (0.03%, n = 1). The incidence of composite angiographic or procedural complications was 2.86% ( n = 87); 233 (7.86%) patients had results suggesting contrast-induced acute kidney injury. Conclusions::These findings indicate that the use of iodixanol in Chinese patients undergoing PCI is associated with a low incidence of MACCEs, confirming its safety in this population.
