Advances in mechanisms of Meckel′s cartilage development and degeneration
10.3760/cma.j.cn112144-20250521-00188
- VernacularTitle:梅克尔软骨发育和消亡机制的研究进展
- Author:
Jingya LI
1
;
Zhiyuan PAN
;
Jiaqiang LIU
;
Jiewen DAI
Author Information
1. 上海交通大学医学院附属第九人民医院口腔颅颌面科 上海交通大学口腔医学院 国家口腔医学中心 国家口腔疾病临床医学研究中心 上海市口腔医学重点实验室，上海市口腔医学研究所，上海 200011
- Publication Type:Journal Article
- Keywords:
Meckel′s cartilage;
Mandibular development;
Mechanistic pathways;
Chondrogenesis
- From:
Chinese Journal of Stomatology
2025;60(9):1060-1070
- CountryChina
- Language:Chinese
-
Abstract:
Meckel′s cartilage (MC) was first delineated in 1820 by the German anatomist Johann Friedrich Meckel the Younger through his examination of human embryos. During early development, MC functions as a supportive structure for the mandible and serves as a template for the subsequent formation of the jaw bones. Ultimately, MC transforms into either skeletal tissue, ligaments, or completely resorbs, integrating with the continuously developing osseous structures. This review elucidates the influence of MC development and degeneration on mandibular morphogenesis, delineating cellular processes and key factors that govern chondrogenic fate determination. The analysis reveals how the alterations of MC affect mandibular and craniofacial development. As a transient cartilaginous structure, investigation into MC may yield valuable insights for understanding oral and craniomaxillofacial pathologies.
