Application of endoscopic ultrasound-guided fine-needle aspiration/biopsy combined with multi-omics in precision diagnosis and treatment of pancreatic ductal adenocarcinoma
10.3760/cma.j.cn115667-20250320-00032
- VernacularTitle:内镜超声引导下穿刺活检术联合多组学在胰腺癌精准诊疗中的应用
- Author:
Yizhou ZHAO
1
;
Yao ZHANG
1
;
Ling ZHANG
1
Author Information
1. 上海交通大学医学院附属瑞金医院消化内科，上海 200025
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Endosonography;
Endoscopic ultrasound-guided fine needle aspiration;
Genomics;
Transcriptomics;
Precision medicine
- From:
Chinese Journal of Pancreatology
2025;25(2):85-89
- CountryChina
- Language:Chinese
-
Abstract:
Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) has overcome the reliance on surgical specimens in traditional pancreatic ductal adenocarcinoma (PDAC) research, enabling minimally invasive acquisition and evaluation of in situ tumor tissues from a large number of patients previously ineligible for surgery. This article systematically discusses the current applications of EUS-FNA/B combined with multi-omics technologies in the precision diagnosis and treatment of pancreatic cancer. We explores how this approach leverages its advantages of minimally invasive sampling and dynamic monitoring to integrate multi-omics analyses, thereby deciphering the dynamic evolution of the tumor microenvironment and drug resistance mechanisms to guide clinical decision-making. Finally, the review highlights future translational research directions aimed at optimizing therapeutic strategies and improving patient outcomes.
