Clinical efficacy of surgical treatment combined with IFX and UST on Crohn's anal fistulae
10.3969/j.issn.1006-5725.2025.06.015
- VernacularTitle:外科治疗联合英夫利昔单抗与乌司奴单抗克对罗恩肛瘘的临床疗效观察
- Author:
Hexue YUAN
1
;
Feng TIAN
;
Hui LI
;
Fang LUO
;
Liang ZHAO
;
Zongjian LIU
;
Chunlai PAN
;
Lijun LIU
;
Na ZHU
Author Information
1. 沈阳市肛肠医院肛肠外科(辽宁 沈阳 110002)
- Publication Type:Journal Article
- Keywords:
pfCD;
surgical treatment;
infliximab;
ustekinumab
- From:
The Journal of Practical Medicine
2025;41(6):872-876
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of combining surgical treatment with biological agents for perianal fistulizing Crohn's disease(pfCD).Methods Sixty patients with perianal fistulizing Crohn's disease(pfCD)admitted to our hospital from May 2021 to December 2023 were randomly allocated into two groups:Treatment Group A(n=30)and Treatment Group B(n=30).Treatment Group A received pfCD surgery combined with inflix-imab(IFX)and azathioprine(AZA),while Treatment Group B underwent pfCD surgery along with ustekinumab(UST)and AZA.The CDAI score,PDAI score,and Assche score were monitored for both groups,and postoperative MRI examinations were conducted to evaluate the healing of pfCD.Results There were statistically significant differences in CDAI,PDAI,and Assche scores between pre-treatment and post-treatment comparisons within treat-ment groups A and B(P<0.05),as well as in the magnitude of change at each time point.Comparisons of CDAI,PDAI,and Assche scores at 8,16,24,and 32 weeks,and PDAI scores at 40 weeks between groups A and B using independent samples t-tests did not yield statistically significant results(P>0.05).However,significant differences were observed for CDAI and Assche scores at 40 weeks(P<0.05).Significant changes in CDAI,PDAI,and Assche scores were noted at 8,16,24,32,and 40 weeks post-treatment within both groups A and B(P<0.05).Multiple comparisons using the LSD method revealed that the changes in these scores at each time point were statistically significant(P<0.05).The data indicate a temporal trend in the changes of CDAI,PDAI,and Assche scores,with group B showing a more rapid decline compared to group A.In terms of fistula response rates,both groups A and B achieved 100%(30/30).However,the clinical healing rate of fistulas was higher in group B at 86.7%(26/30)compared to 76.7%(23/30)in group A.Conclusion The combination of surgical treatment with IFX/UST plus AZA is safe and effective for treating pfCD.However,the long-term efficacy of combining surgical treatment with UST appears to be superior.
