Effect of short-term repeated administration of several psychoactive drugs on locomotor activity and cerebral monamine transmitters in mice
10.3760/cma.j.issn.1007-6239.2001.01.003
- VernacularTitle:短期重复使用几种精神药物对小鼠自主活动和脑单胺递质的影响
- Author:
Hao ZHAN
1
;
Guixiang TANG
;
Yimei XIN
Author Information
1. 空军航空医学研究所
- Publication Type:Journal Article
- From:
Chinese Journal of Aerospace Medicine
2001;12(1):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of short-term repeated administration of several psychoactive drugs on locomotor activity and cerebral monamine transmitters in mice and evaluate tolerance of drug action and their side-effects. Methods Male mice were used as subjects. The experiment of central stimulants was divided into 3 groups (n=6 each): ①control;②caffeine(Caf) 30 mg/kg; ③dexamphetamine(Dex) 10 mg/kg. The experiment of hypnotics included 4 groups: ①control; ②triazolam (TZ) 0.04 mg/kg;③seconal (Sec) 60 mg/kg; ④melatonin (Mel) 120 mg/kg. These drugs were given orally to the mice once daily for 7 days. Body weight and locomotor activity were determined on first day and 7th day. After repeated administration of Dex and TZ for 7 days, monamine transmitters and their metabolites in mouse brain were determined by reverse phase HPLC with electrochemical detector. Results ①There was no significantly difference of body weight between the control and drug-treated groups. ②Stimulating action of Caf and Dex was significantly increased on 7th day (P<0.05, compared with first day). ③Although the significant sedative effect of hypnotics remained after repeated administration of hypnotics for 7 days, their potency was reduced(P<0.05, compared with first day). ④ No significant changes of monamine transmitters were found in cerebral cortices of mice after repeated administration of Dex and TZ for 7 days; but DOPAC and 5-HIAA in Dex group and 5-HIAA in TZ group was significantly decreased (P<0.05, compared with the control). Conclusion ①The sedative effect of several hypnotics was decreased after repeated medication; ②Dex and TZ might have detrimental effects on some monamine transmitter metabolites in mouse brain after continuous administration for one week.
