Correlation between iron death-related gene expression level and myocardial dysfunction and prognosis in sepsis
10.3969/j.issn.1006-5725.2025.06.011
- VernacularTitle:铁死亡相关基因表达水平与脓毒症心肌功能障碍及预后的相关性
- Author:
Tong DUAN
1
;
Qi WU
1
;
Hui LIU
1
Author Information
1. 长沙市第一医院急诊科(湖南 长沙 410005)
- Publication Type:Journal Article
- Keywords:
iron death;
sepsis;
myocardial dysfunction;
prognosis;
correlation
- From:
The Journal of Practical Medicine
2025;41(6):846-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the correlation between ferroptosis-related gene expression levels and myocardial dysfunction as well as prognosis in sepsis patients.Methods Eighty-five sepsis patients admitted to our hospital from May 2023 to August 2024 were categorized into two groups based on the presence of myocardial dysfunction:the impaired group(n=39)and the non-impaired group(n=46).The mRNA expression levels of cytochrome P450 oxidoreductase(POR),solute carrier family 7 member 5(SLC7A5),and signal transducer and activator of transcription 3(STAT3)were measured.Multivariate logistic regression analysis was conducted to examine the correlation between the expression levels of iron death-related genes and sepsis-induced myocardial dysfunction(SIMD).Kaplan-Meier survival curves were plotted to evaluate the relationship between the expression levels of iron death-related genes and the prognosis of sepsis patients.Results In patients with sepsis,the disorder group exhibited higher male proportions,age,and expression levels of POR,SLC7A5,and STAT3 compared to the non-disorder group(P<0.05).After adjusting for potential confounders such as gender and age,the expression levels of POR,SLC7A5,and STAT3 remained independent predictors of SIMD(P<0.05).The ROC curve analysis revealed that the AUC for POR expression in predicting SIMD was 0.677(95%CI:0.561～0.792),with a sensitivity of 87.20%and specificity of 54.30%.For SLC7A5,the AUC was 0.844(95%CI:0.749～0.939),with a sensitivity of 74.40%and specificity of 93.50%.STAT3 had an AUC of 0.690(95%CI:0.570～0.809),with a sensitivity of 69.20%and specificity of 71.70%.During the follow-up period,69 patients(81.18%)survived,while 16(18.82%)did not.Kaplan-Meier survival analysis indicated that POR and SLC7A5 expression levels were significantly associ-ated with the 28-day survival rate of septic patients(χ2=6.048/10.143,P<0.05),whereas STAT3 expression showed no significant correlation(χ2=2.149,P>0.05).Conclusion The expression levels of POR,SLC7A5 and STAT3 are closely related to SIMD,and the expression levels of POR and SLC7A5 are significantly related to the prognosis of sepsis patients.
