Research progress of umbilical cord blood in the diagnosis of early-onset neonatal sepsis
10.3760/cma.j.cn101070-20250122-00050
- VernacularTitle:脐血诊断新生儿早发型败血症研究进展
- Author:
Zongli CHEN
1
;
Lu LI
1
;
Keyong LUO
1
;
Liang JIANG
1
Author Information
1. 遵义医科大学第三附属医院（遵义市第一人民医院）新生儿科，遵义 563000
- Publication Type:Journal Article
- Keywords:
Infant, newborn;
Early-onset sepsis;
Umbilical cord blood;
Biomarker;
Umbilical cord blood culture
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(12):953-956
- CountryChina
- Language:Chinese
-
Abstract:
Early-onset neonatal sepsis (EONS) is a systemic inflammatory response syndrome caused by bacterial and fungal infections within 3 days after birth, which is one of the important causes of poor prognosis and even death in neonates.Early accurate diagnosis and timely treatment are crucial to improving the prognosis and reducing the mortality and unreasonable use of antibiotics.Because umbilical cord blood shares the same cell composition with fetal peripheral blood at the end of pregnancy, and has the advantages of easy availability and painlessness, many researchers have been devoted to exploring umbilical cord blood markers related to the diagnosis of EONS in recent years.Most studies suggest that umbilical cord blood culture, procalcitonin, C-reactive protein and interleukin-6 should be routinely used as single indicators for clinical diagnosis of EONS.The combination of two or more biomarkers may be more accurate for the diagnosis of EONS, which, however, needs to be confirmed with more trials, and it is also a significant direction of future research.In this article, progress in relevant research was reviewed in order to provide reference for early diagnosis of EONS.
