In vitro models of periodontitis: research progress
10.3760/cma.j.cn112144-20241126-00446
- VernacularTitle:牙周炎体外研究模型的进展
- Author:
Qiuyue FU
1
;
Rui ZHANG
;
Shaohua GE
Author Information
1. 山东大学齐鲁医学院口腔医学院 口腔医院牙周科 山东省口腔组织再生重点实验室 口腔生物材料与组织再生山东省工程研究中心 山东省口腔疾病临床医学研究中心，济南 250012
- Publication Type:Journal Article
- Keywords:
Periodontitis;
In vitro;
In vitro models;
Models, animal;
Tissue engineering;
Organ-on-a-chip
- From:
Chinese Journal of Stomatology
2025;60(6):656-661
- CountryChina
- Language:Chinese
-
Abstract:
Due to the high prevalence of periodontitis, the control of periodontal inflammation, as well as the regeneration and repair of periodontal tissues have attracted extensive attentions. To better understand the mechanism of periodontal diseases, in vivo and in vitro models are usually required. With the rapid development of tissue engineering, in vitro models with the advantages of easy observation, high controllability, low cost, and high efficiency has become a unique choice for current research. In vitro models of periodontitis are no longer limited to cellular models, researchers are increasingly inclined to develop simple, effective, and realistic models to simulate the periodontal microenvironment. This article reviews in vitro models of periodontitis that have been successfully established, aiming to provide researchers with new ideas to simulate the human periodontitis microenvironment in vitro, which is helpful to explore the pathogenesis of periodontitis.
