The treatment of children with laryngopharyngeal reflux
10.3760/cma.j.cn101070-20250623-00473
- VernacularTitle:儿童咽喉反流的治疗
- Author:
Hongtian WANG
1
Author Information
1. 首都医科大学附属北京世纪坛医院变态反应科，北京 100038；解放军总医院第一医学中心耳鼻咽喉头颈外科，北京 100853
- Publication Type:Journal Article
- Keywords:
Child;
Life style;
Laryngopharyngeal reflux;
Anti-acid therapy;
Surgery
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(11):841-846
- CountryChina
- Language:Chinese
-
Abstract:
The management of pediatric laryngopharyngeal reflux disease (LPRD) should adopt a comprehensive strategy that prioritizes " lifestyle modifications as the foundation, pharmacotherapy as the mainstay, and surgical intervention as an adjunct." Lifestyle interventions serve as the primary measure, encompassing dietary adjustments (low-fat/low-sugar diet, less but frequent meals, avoidance of irritants, and pre-sleep fasting), postural therapy (elevating the bedhead and side-lying position during sleep), psychological counseling, and weight management.Proton pump inhibitors are the preferential pharmacological therapy, which can mitigate mucosal injury through gastric acid suppression, but an adequate dosage and duration are required to achieve the effect.Combination therapy with H2 receptor antagonists effectively addresses nocturnal acid breakthrough.Novel potassium ion competitive acid blockers are emerging as alternatives due to their rapid onset and sustained acid-suppressive effects.Adjuvant therapies may include prokinetic agents and mucosal protectants.Surgical intervention is reserved for cases with anatomical abnormalities (e.g., adenoid hypertrophy and hiatal hernia) or refractory disease and they require rigorous risk-benefit assessment.Pediatric LPRD management should emphasize vigilant monitoring of adverse effects, patient education, and long-term follow-up to sustain therapeutic efficacy, reduce recurrence rates and improve quality of life.
