Research progress on the diagnosis of laryngopharyngeal reflux in children
10.3760/cma.j.cn101070-20250501-00323
- VernacularTitle:儿童咽喉反流诊断研究进展
- Author:
Zhifei XU
1
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院呼吸科，北京 100045
- Publication Type:Journal Article
- Keywords:
Laryngopharyngeal reflux;
Child;
Auxiliary examination;
Diagnosis
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(11):835-840
- CountryChina
- Language:Chinese
-
Abstract:
Laryngopharyngeal reflux disease (LPRD) is a chronic inflammatory condition caused by the backflow of gastric and duodenal contents to the upper respiratory tract above the upper esophageal sphincter.In children, its occurrence is closely associated with factors such as immature development of the esophageal sphincter, prolonged supine positioning, and heightened sensitivity of the laryngopharyngeal mucosa.The clinical manifestations of pediatric LPRD are often insidious and primarily present as nonspecific symptoms, including chronic cough, hoarseness, and a sensation of a foreign body in the throat.These symptoms can be easily confused with upper respiratory tract infections, asthma, and other conditions, making diagnosis challenging.Currently, LPRD diagnosis relies on a multidimensional assessment, including a detailed medical history, physical examination, and auxiliary investigations such as 24-hour multichannel intraluminal impedance-pH monitoring, Dx-pH monitoring, and salivary pepsin testing.Additionally, empirical trials of acid suppression therapy can serve as a supplementary diagnostic approach.However, the diagnosis of pediatric LPRD remains challenging due to nonspecific symptoms, poor tolerance to examinations, and the lack of standardized diagnostic criteria.Future efforts should focus on optimizing noninvasive diagnostic techniques and establishing pediatric-specific diagnostic standards to improve early detection rates and the precision of treatment.
