Detection of two new phencyclidine-type hallucinogens in blood by SLE-UPLC-MS/MS
10.13618/j.issn.1001-5728.2025.02.013
- VernacularTitle:SLE-UPLC-MS/MS分析血液中2种苯环利定类新型致幻剂
- Author:
Wencan ZENG
1
;
Jia LIN
Author Information
1. 福建省测试技术研究所,福建 福州 350003
- Publication Type:Journal Article
- Keywords:
Forensic toxicology;
MXE;
2-oxo-PCE;
Blood;
SLE-UPLC-MS/MS
- From:
Chinese Journal of Forensic Medicine
2025;40(2):203-206,212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a supported liquid-liquid extraction-ultra-performance liquid chromatography-tandem mass spectrometry(SLE-UPLC-MS/MS)method for detecting methoxetamine(MXE,2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone)and 2-oxo-PCE(2-(ethylamino)-2-phenylcyclohexan-1-one)in blood.Methods Blood samples were extracted and purified using supported liquid-liquid extraction columns.An electrospray ionization source and multiple reaction monitoring mass spectrometry were used for qualitative and quantitative analysis of MXE and 2-oxo-PCE in blood samples.Results The limits of detection for MXE and 2-oxo-PCE in blood were 0.15 ng/mL and 0.17 ng/mL,respectively.Both compounds showed good linearity in the range of 0.5-500 ng/mL(r2>0.999),with recovery rates ranging from 90.7%to 98.4%.Conclusion The established qualitative and quantitative analytical method is simple,rapid,reliable,and highly sensitive,making it suitable for the detection and identification of MXE and 2-oxo-PCE in blood.
