Research on the application of metformin in ocular diseases
10.3760/cma.j.cn115989-20220916-00432
- VernacularTitle:二甲双胍在眼部疾病中的应用研究
- Author:
Chunxi WANG
1
;
Xiaomin ZHANG
1
Author Information
1. 天津医科大学眼科医院 天津医科大学眼视光学院 天津医科大学眼科研究所 国家眼耳鼻喉疾病临床医学研究中心天津市分中心 天津市视网膜功能与疾病重点实验室，天津 300384
- Publication Type:Journal Article
- Keywords:
Metformin;
Ocular disease;
AMP-activated protein kinase;
Review
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(11):1065-1069
- CountryChina
- Language:Chinese
-
Abstract:
Metformin is a common oral hypoglycemic drug, which has an important role in improving insulin resistance and regulating the level of glucolipid metabolism.With the widespread use of metformin in recent years, new evidence suggests that it also regulates multiple biological processes such as autophagy, inflammation, angiogenesis, and fibrosis, which may provide the theoretical basis for the use of metformin in ocular disease.Current studies have implicated that metformin has great potential in ocular therapy in preclinical and clinical applications, especially for patients with diabetic retinopathy, where metformin has an important role in delaying disease progression by inhibiting hyperglycemia-induced retinal inflammation, oxidative injury, and vascular endothelial growth factor signaling pathway.For nondiabetic ocular disease, metformin ameliorated the disease course by modulating cellular metabolism, improving oxidative stress and autophagy, and downregulating pro-inflammatory cytokines.Considering the multifaceted roles beyond glucose-lowering effects, as the advantage of safety profile and low cost, metformin has the potential as a novel therapeutic strategy for the treatment of ocular disease.This article reviews the research progress on the application of metformin in ocular diseases.
