Research progress on mechanism of miRNA regulating H-type blood vessels in bone metabolic diseases and intervention effect of active ingredients of traditional Chinese medicines
- VernacularTitle:miRNA调控H型血管在骨代谢疾病中的作用机制及中药活性成分干预作用研究进展
- Author:
Jia-xuan FAN
1
;
Wei ZHANG
;
Rui CUI
;
Lin-zhong CAO
Author Information
- Publication Type:Journal Article
- Keywords: microRNA; H-type vessel; angiogenesis-osteogene-sis coupling; bone homeostasis; bone metabolism; active ingre-dients of traditional Chinese medicine
- From: Chinese Pharmacological Bulletin 2025;41(4):606-612
- CountryChina
- Language:Chinese
- Abstract: microRNA(miRNA),as a short non-coding RNA molecule,regulates bone-immune signal and stress response through transcription,translation as well as the combination of shear process,exerting the effect of promoting angiogenesis and repairing damage bone;type H vessels play a role in the cou-pling of angiogenesis and osteogenesis in the formation of new bone and promoting bone regeneration at the defect site.In re-cent years,miRNA regulates hypoxia inducible factor 1α(HIF-1 α)/vascular endothelial growth factor(VEGF),Notch,plate-let-derived growth factor-BB(PDGF-BB),Wnt/glycogen syn-thase kinase-3 β(GSK3 β)to affect the migration,recruitment,proliferation and differentiation of endothelial cells(ECs)and osteoblast(OB),promote the coupling of H-type vessels and os-teoblasts to improve bone homeostasis,and then prevent and treat bone metabolic diseases.This article explains the role of miRNA in regulating H-type vascular osteogenic coupling to provide tar-gets and pathways for improving bone homeostasis.In addition,the active ingredients of traditional Chinese medicine affect the differential expression of miRNA to promote H-type angiogenesis and provide strategies for clinical prevention and treatment of bone metabolic diseases.
