Distribution and antimicrobial resistance profiles of carbapenem-resistant Enterobacterales in Xinjiang Uygur Autonomous Region from 2017 to 2021
10.16718/j.1009-7708.2025.02.009
- VernacularTitle:2017-2021年新疆维吾尔自治区耐碳青霉烯类肠杆菌目细菌的分布特征及耐药性监测
- Author:
Yan JIANG
1
;
Na CHEN
1
;
Ping JI
1
;
Hui LI
1
Author Information
1. 新疆医科大学第一附属医院医学检验中心,乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
bacterial resistance surveillance;
carbapenem-resistant Enterobacterales;
carbapenem-resistant Klebsiella pneumoniae;
carbapenem-resistant Escherichia coli;
carbapenem-resistant Enterobacter cloacae
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(2):174-180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changing prevalence and antimicrobial resistance profiles of carbapenem-resistant Enterobacterales(CRE)in Xinjiang Uygur Autonomous Region from 2017 to 2021.Methods Relevant CRE data in hospitals across Xinjiang from 2017 to 2021 were summarized according to the unified protocol of the National Antimicrobial Resistance Surveillance Network.The data were statistically analyzed by WHONET 5.6 software.Results A total of 5 071 CRE strains were identified from 165 786 strains of Enterobacterales in Xinjiang in the five-year period.The prevalence of CRE was 2.8％in 2017,3.2％in 2018,2.9％in 2019,3.1％in 2020,and 3.2％in 2021.The highest prevalence(3.3％)was in northern Xinjiang and the lowest prevalence(0)was in eastern Xinjiang.The prevalence of CRE in tertiary hospitals was higher than that in secondary hospitals.The top three species among the 5 071 CRE strains were carbapenem-resistant Klebsiella pneumoniae,carbapenem-resistant Escherichia coli,and carbapenem-resistant Enterobacter cloacae.The CRE strains were mainly isolated from the patients in ICU(34.6％),respiratory ICU(8.1％),neurosurgery(7.5％),and respiratory medicine(5.2％).The distribution of CRE species varied with patient age and gender.The carbapenem-susceptible Enterobacterales and CRE strains isolated from children were less resistant to the commonly used antibiotics in clinical practice than the corresponding strains isolated from adult patients.Conclusions The prevalent CRE strains from patients in Xinjiang are still serious.It is necessary to strengthen the surveillance of bacterial resistance and carry out multidisciplinary linkage to curb the spread and outbreak of CRE.
