Influence of Metabolic Associated Fatty Liver Disease on the Severity of Acute Pancreatitis
10.11969/j.issn.1673-548X.2025.03.028
- VernacularTitle:代谢相关脂肪性肝病对急性胰腺炎严重程度的影响
- Author:
Qiange WU
1
;
Kejian WU
Author Information
1. 221000 徐州医科大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Metabolic associated fatty liver disease;
Acute pancreatitis;
Severity
- From:
Journal of Medical Research
2025;54(3):152-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of metabolic associated fatty liver disease(MAFLD)on the severity of acute pan-creatitis(AP)by exploring the relationship between them.Methods The clinical data of 526 AP patients who were admitted to the Affil-iated Hospital of Xuzhou Medical University from January 2021 to March 2023 were retrospectively analyzed.The severity of AP was as-sessed by the revised Atlanta classification,bedside index for severity in acute pancreatitis(BISAP)score,and modified CT severity in-dex(MCTSI)score.The patients were divided into MAFLD group(n=294)and non-MAFLD group(n=232)according to the pres-ence or absence of MAFLD.The two groups were compared in terms of the the indices such as general data,laboratory indicators,severi-ty,complications,the length of hospital stay.Univariate and multivariate Logistic regression analysis were also used to screen the inde-pendent risk factors for the severity of AP.Results The incidence of moderately severe acute pancreatitis(MSAP)and severe acute pan-creatitis(SAP)in MAFLD group were higher than those in non-MAFLD group,the BISAP score,MCTSI score,the incidence of local and systemic complications and.the duration of hospitalization and hospital stay in ICU for patients in MAFLD were also higher than those in non-MAFLD.Multivariable Logistic regression analysis showed that MAFLD was an independent risk factor for MSAP and SAP.Conclusion MAFLD increases the risk of AP.The presence of MAFLD portends a higher risk of MSAP and SAP,as well as higher inci-dence of local and systemic complications.
