Predictive value of dual-energy CT quantitative parameters in differential diagnosis and pathological aggressiveness of lung adenocarcinoma
10.3969/j.issn.1002-1671.2025.03.009
- VernacularTitle:双能量CT定量参数对肺腺癌鉴别诊断及病理侵袭性的预测价值
- Author:
Yan HUANG
1
;
Yingxun TAN
1
;
Le LIN
1
;
Shuke SUN
1
;
Lishan WEI
1
Author Information
1. 河池市第一人民医院影像科,广西 河池 546300
- Publication Type:Journal Article
- Keywords:
lung adenocarcinoma;
dual-energy computed tomography;
quantitative analysis;
diagnosis;
aggressiveness
- From:
Journal of Practical Radiology
2025;41(3):394-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of dual-energy computed tomography(DECT)quantitative parameters in the diagnosis and pathological aggressiveness of lung adenocarcinoma.Methods A total of 174 patients with lung cancer were pro-spectively selected.All patients underwent DECT examination,and the types of lung cancer were determined according to the patho-logical tissue.According to the pathological classification,they were divided into lung adenocarcinoma group(n=99),lung squamous cell carcinoma group(n=47)and small cell lung cancer group(n=28).According to whether the lung adenocarcinoma patients had pathological aggressiveness,they were divided into invasive group(n=34)and non-invasive group(n=65).Receiver operating char-acteristic(ROC)curve was used to diagnose the predictive value of DECT quantitative parameters in the diagnosis and pathological aggressiveness of lung adenocarcinoma.Results The normalized iodine concentration(NIC)and k in venous phase of lung adenocar-cinoma group were higher than those in lung squamous cell carcinoma group and small cell lung cancer group(P<0.05).ROC curve analysis showed that the combined diagnosis value of NIC and k in venous phase was higher(P<0.05).The lobular proportion,vac-uolar proportion,pleural indentation proportion,vascular cluster proportion,effective atomic number(Eff-Z),NIC and k in arterial phase,and NIC and k in venous phase in invasion group were higher than those in non-invasion group(P<0.05).Logistic regression analysis showed that pleural indentation,NIC in arterial phase and NIC in venous phase were risk factors for pathological aggerssive-ness in lung adenocarcinoma patients(P<0.05).ROC curve analysis showed that the combination of NIC in arterial phase and NIC in venous phase had higher value in predicting the pathological aggressiveness of lung adenocarcinoma(P<0.05).Conclusion The combination of NIC and k in venous phase is effective in the diagnosis of lung adenocarcinoma,while NIC in arterial phase and NIC in venous phase have high predictive values for the aggressiveness of lung adenocarcinoma.
