Comparative analysis of clinical and imaging features in serum MOG-IgG positive adult and pediatric patients
10.3969/j.issn.1002-1671.2025.03.004
- VernacularTitle:血清MOG-IgG阳性成人和儿童患者临床及影像学特征比较分析
- Author:
Hongji ZHU
1
;
Meimei JIANG
;
Ya'nan LU
;
Juan LU
;
Ying LIU
Author Information
1. 中国科学技术大学附属第一医院(安徽省立医院)影像科,安徽 合肥 230001
- Publication Type:Journal Article
- Keywords:
adult;
pediatric;
anti-myelin oligodendrocyte gly-coprotein-IgG;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(3):372-375,380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize and analyze the clinical and imaging features in patients with initial onset of anti-myelin oli-godendrocyte glycoprotein-IgG(MOG-IgG)associated disease(MOGAD).Methods The clinical and MRI data of 39 patients with serum MOG-IgG positive were analyzed retrospectively.Clinical features(including history of prior infection,initial symptoms and clinical phenotypes,cerebrospinal fluid examination,and serum antibody levels)and location,distribution,and enhancement patterns of lesions were all compared between adult and pediatric groups.Results Blurred vision was the most common initial symptom,with no statistically significant difference between the two groups.Compared to the adult group,the pediatric group more frequently presented with acute disseminated encephalomyelitis(ADEM)as the clinical phenotype.There were no statistically significant differ-ences between the two groups in cerebrospinal fluid examination results,including leukocyte count,protein content,and oligoclonal bands(OCB)positive.The pediatric group showed a higher prevalence of lesions in the cortical and subcortical white matter,deep white matter,and basal ganglia regions compared with the adult group.There was no statistically significant difference in the inci-dence of optic neuritis between the two groups.Spinal cord inflammation predominantly affected the cervical and thoracic segments,with central gray matter involvement presenting as the"H-sign".Conclusion The clinical and imaging features of MOGAD exhibit certain variations across different patient populations.Accurate recognition and early diagnosis of MOGAD and prompt examination and treatment are instrumental in improving patients'prognosis.
