Quantification of hippocampal GABA+and Glx based on MEGA-PRESS sequence in temporal lobe epilepsy
10.3969/j.issn.1002-1671.2025.03.005
- VernacularTitle:基于MEGA-PRESS序列的海马GABA+及Glx定量在颞叶癫痫的研究
- Author:
Xucong WANG
1
;
Wenrui YANG
1
;
Bing CHEN
1
Author Information
1. 宁夏医科大学总医院放射科,宁夏 银川 750003
- Publication Type:Journal Article
- Keywords:
temporal lobe epilepsy;
Meshcher-Garwood point resolved spectroscopy;
hippocampus sclerosis;
γ-aminobutyric acid
- From:
Journal of Practical Radiology
2025;41(3):376-380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the levels of γ-aminobutyric acid complex(GABA+),glutamate and glutamine(Glx)in the bilateral hippocampal region of patients with temporal lobe epilepsy(TLE),and to analyze the potential clinical correlation.Methods The levels of GABA+and Glx in the hippocampal region of 23 TLE patients(TLE group)and 20 healthy volunteers(control group)were measured by quantitative Meshcher-Garwood point resolved spectroscopy(MEGA-PRESS)sequence.The differences of metabolite levels in bilateral hippocampal region were compared.At the same time,the differences of metabolites in hippocampal region between control group,TLE affected subgroup and TLE unaffected subgroup were compared.Spearman correlation coefficient was used to evaluate the correlation between hippocampal region metabolite levels and clinical.Results The levels of two metabolites in bilateral hipp-ocampal region of the control group were symmetrical distribution.The GABA+level in the affected hippocampal region of the TLE group was significantly lower than that in the bilateral hippocampal region of the control group,and the Glx level in the affected hip-pocampal region of the TLE group was not significantly different from that of the control group.The level of GABA+in the affected hippocampal region of the TLE group was significantly lower than that of the unaffected[(1.65±0.85)i.u.vs(1.86±0.58)i.u.;(1.68±0.67)i.u.vs(1.80±0.81)i.u.];The level of GABA+in the affected hippocampal region of the TLE subgroup with cogni-tive impairment(CI)was significantly lower than that of the TLE subgroup with normal cognition,and there was no significant difference in Glx content between the two subgroups(P>0.05).The level of GABA+in the TLE subgroup with CI was negatively correlated with the course of disease and attack frequency(r=-0.90,P<0.05;r=-0.91,P<0.05).Conclusion The change of GABA+level in hippocampal region is a marker of TLE occurrence and disease progression,and is closely related to CI.
