Analysis of the impact of Parkinson's disease combined with cerebral small vessel disease on cognitive function based on MRI
10.3969/j.issn.1002-1671.2025.03.001
- VernacularTitle:基于MRI分析帕金森病合并脑小血管病对患者认知功能的影响
- Author:
Zhi CHEN
1
;
Huihui TAN
;
Xiaobo LI
;
Gejuan ZHANG
;
Junle YANG
Author Information
1. 西安市第三医院神经内科,陕西 西安 710000
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
cerebral small vessel disease;
magnetic resonance imaging;
cognitive impairment
- From:
Journal of Practical Radiology
2025;41(3):359-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the differences and correlations of imaging parameters in patients with Parkinson's disease(PD)combined with cerebral small vessel disease(CSVD)with different cognitive functions based on MRI.Methods A retrospective selection was conducted on 192 PD patients combined with CSVD.According to the Montreal cognitive assessment(MoCA)and mini-mental state examination(MMSE)scores,they were divided into cognitive impairment PD group(n=69)and cognitive normal PD group(n=123),and the clinical data and MRI imaging parameters of the two groups were compared.Results The age and drinking history of the cog-nitive impairment PD group were higher than those of the cognitive normal PD group(P<0.05);the lacune of presumed vascular origin(LPVO)score,periventricular white matter hyperintensity(PVWMH)score,basal ganglia-perivascular space(BG-PVS)score,brain atrophy(BA)score,and CSVD total score in the cognitive impairment PD group were higher than those in the cognitive normal PD group(P<0.05),while there was no statistically significant difference in deep white matter hyperintensity(DWMH)score,cen-trum semiovale perivascular space(CS-PVS)score,and cerebral microbleed(CMB)score between the two groups(P>0.05);Multi-variate logistic analysis showed that age,LPVO score,BG-PVS score,BA score,and CSVD total score were independent influencing factors of cognitive impairment(P<0.05).Conclusion There are differences in imaging parameters such as LPVO score,PVWMH score,BG-PVS score,BA score,and CSVD total score among PD patients combined with CSVD with different cognitive functions,and they are correlated with MMSE and MoCA scores.
