Advance in biomechanical factors regulating angiogenesis in atherosclerotic plaques
10.20039/j.cnki.1007-3949.2025.02.002
- VernacularTitle:生物力学因素调控动脉粥样硬化斑块内血管新生的研究进展
- Author:
Chengxiu PENG
1
;
Hanxiao CHEN
;
Yuhan ZENG
;
Yujing FENG
;
Yuhao LI
;
Yang SHEN
Author Information
1. 四川大学华西基础医学与法医学院生物医学工程研究室,四川省成都市 610041
- Publication Type:Journal Article
- Keywords:
atherosclerosis plaque;
angiogenesis;
mechanical microenvironment
- From:
Chinese Journal of Arteriosclerosis
2025;33(2):102-107
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis within atherosclerotic plaques is a critical determinant of plaque stability.The biome-chanical microenvironment,consisting of fluid shear force,plaque structural stress,and matrix stiffness,serves as signifi-cant factors in mediating plaque angiogenesis.Endothelial cells respond to mechanical signals and participate in plaques neovascularization through force chemical signal transduction mechanisms.This review provides an overview of the mecha-nisms by which mechanical factors regulate angiogenesis within plaques and offers a novel therapeutic approach for the pre-vention and treatment of atherosclerosis.
