Efficacy and the Effects on Cardiac Function of HHHFNC as Initial Treatment for Preterm Infants with Neonatal Respiratory Distress Syn-drome
10.11969/j.issn.1673-548X.2025.03.021
- VernacularTitle:加温湿化高流量鼻导管通气初始治疗早产儿呼吸窘迫综合征疗效及对心功能的影响
- Author:
Honglin LEI
1
;
Hongshan SHI
1
;
Chongxun ZHANG
1
Author Information
1. 221009 徐州市中心医院(徐州医科大学徐州临床学院)新生儿科
- Publication Type:Journal Article
- Keywords:
Noninvasive ventilation;
Respiratory distress syndrome;
Newborn;
Natriuretic peptide;
Tei index
- From:
Journal of Medical Research
2025;54(3):114-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and the effects on cardiac function of heated humidified high-flow nasal cannula(HHHFNC)and nasal continuous positive airway pressure(NCPAP)as initial treatment for preterm infants with neonatal respiratory dis-tress syndrome(NRDS).Methods The preterm infants with NRDS,gestational age＜35 weeks and requiring noninvasive ventilation ad-mitted to Xuzhou Central Hospital from January 2021 to November 2023 were enrolled for a prospective study and were randomly divided into the HHHFNC group and NCPAP group.The initial treatment was performed using HHHFNC and NCPAP respectively.The efficacy,safety and effects on cardiac function were compared.Results 55 cases were enrolled in HHHFNC group,and 53 cases were enrolled in NCPAP group.There were no statistically significant difference between the two groups in the number and total dose of the use of pulmona-ry surfactant,the number of apneas within 24hours of enrollment,the duration of noninvasive ventilation,the cases of noninvasive ventila-tion failure,the age achieving total enteral nutrition,the length and costs of hospitalization(P＞0.05).The incidence of nasal injury in the HHHFNC group was significantly lower than that in the NCPAP group(0 vs 11.3％,P=0.032).There were no statistically signifi-cant difference between the two groups in the pneumothorax,stage Ⅱ-Ⅲ necrotizing enterocolitis,hemodynamically significant patent ductus arteriosus,grade Ⅱ-Ⅳ intraventricular hemorrhage,bronchopulmonary dysplasia,and retinopathy of prematurity requiring treat-ment at the first screening(P＞0.05).There were no statistically significant difference between the two groups in fraction of inspired oxy-gen and arterial partial pressure of carbon dioxide,Plasma B-type natriuretic peptide(183.9±48.5ng/L vs 187.8±51.4ng/L,189.4±50.9ng/L vs 180.2±45.1ng/L)and Tei index of right ventricle(0.38±0.05 vs 0.40±0.06,0.38±0.06 vs 0.39±0.06)at 24±6h and 48±6h after noninvasive ventilation(P＞0.05).Conclusion In the initial treatment for preterm infants(gestational age＜35 weeks)with NRDS who need noninvasive ventilation,the efficacy of HHHFNC was similar to that of NCPAP,and the rate of nasal injury was lower.Other safety indexes and the effects on cardiac function were similar.
