Role of proteins containing leucine rich repeat motif in ophthalmic diseases
10.3760/cma.j.cn115989-20220813-00374
- VernacularTitle:富含亮氨酸重复序列相关蛋白在眼科疾病中的作用
- Author:
Yao WEI
1
;
Lingxi JIANG
1
;
Yi SHI
1
Author Information
1. 四川省医学科学院·四川省人民医院 遗传性疾病四川省重点实验室，成都 610072
- Publication Type:Journal Article
- Keywords:
Leucine rich repeat;
Eye diseases;
Pathogenesis;
LRR proteins
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(10):951-957
- CountryChina
- Language:Chinese
-
Abstract:
Leucine rich repeat (LRR) is a common protein structure that exists in many kinds of proteins and plays a crucial role in maintaining the biological function of these proteins.Eye tissue is an important sensory system and connects with nervous system through the optic nerve.There are relevant studies to confirm that a variety of LRR proteins in eye tissue, such as small leucine-rich proteoglycans, keratocan, leucines-rich repeat-containing 8, NOD-like receptor thermal protein domain associated protein 3 and NYX, which take part in multiple ocular diseases including myopia, retinal diseases, glaucoma, uveitis, night blindness, corneal diseases and eye fibropathy.This article focuses on the functional research of LRR-related proteins in ophthalmic diseases.The hope is that focusing on LRR-related proteins crucial to ocular development will provide new ideas for the diagnosis and treatment of various ophthalmic diseases.
