Resolving the diagnostic dilemma of gastroesophageal reflux disease: multimodal integration strategies and novel perspectives for precision assessment
10.3760/cma.j.cn441530-20250808-00296
- VernacularTitle:胃食管反流病的诊断困境与破局核心：多模态整合策略与精准评估新视角
- Author:
Dianxuan JIANG
1
;
Songfeng CHEN
1
;
Mengyi LI
1
;
Yinglian XIAO
1
Author Information
1. 中山大学附属第一医院消化内科，广州 510080
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux disease;
Diagnosis;
Multimodal diagnostic approach
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(10):1112-1117
- CountryChina
- Language:Chinese
-
Abstract:
Gastroesophageal reflux disease (GERD) is characterized by significant clinical heterogeneity. Conventional diagnostic approaches, including symptom-based questionnaires, empirical acid suppression trials, and single-modality objective tests, demonstrate limited sensitivity and specificity, often resulting in diagnostic inaccuracies and inefficient resource utilization. To overcome these diagnostic challenges, this article provides a systematic review of recent advancements and ongoing debates in GERD diagnostics, with a focus on the diagnostic value of multimodal parameters as outlined in the Lyon Consensus 2.0. It also explores the clinical relevance of emerging auxiliary diagnostic metrics. We emphasize that integrating clinical symptomatology, endoscopic findings, esophageal physiological measurements, and psychosocial factors (augmented by composite scoring systems and artificial intelligence), offers a promising strategy for accurate diagnosis and personalized treatment of GERD.
