Related factors of hyperuricemia in adolescents with bipolar disorder
10.3969/j.issn.1000-6729.2025.01.06
- VernacularTitle:青少年双相障碍患者高尿酸血症的相关因素
- Author:
Yuyong SUN
1
;
Xiaoyan LIU
1
;
Wenjing CUI
1
;
Pengfei GUO
1
;
Yong XIA
1
Author Information
1. 浙江大学医学院附属精神卫生中心/杭州市第七人民医院,杭州 310013
- Publication Type:Journal Article
- Keywords:
adolescent;
bipolar disorder;
hyperuricemia;
body mass index;
metabolic syndrome;
triglyceride
- From:
Chinese Mental Health Journal
2025;39(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the related factors of hyperuricemia(HUA)in adolescents with bipolar disorder.Methods:Fifty-nine adolescent patients with bipolar disorder and 60 normal controls were select-ed.General demographic and clinical data were collected.Serum uric acid(UA),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FPG),fructosamine(FA)and other physiological indices were detected.The Hamilton Depression Scale 17(HAMD-17)and Bech-Rafaelsen Mania Scale(BRMS)were used to evaluate the emotional symptoms of the patients.Results:The detection rate of HUA was higher in the adolescent patients with bipolar disorder than in the normal control group(30.5％vs.18.3％,P＜0.05),and was higher in manic episode than in depressive episode(48.2％vs.20.8％,P＜0.05).Unconditioned logistic regression analysis showed that high level of TG and high BMI were risk factors for hyperuricemia in adolescents with bipolar disorder(OR=2.51,1.34).Conclusion:This study shows that adolescents with bipolar disorder may have a higher risk of HUA than normal controls,and its oc-currence is associated with high TG level and BMI.
